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Hypervitaminosis D is a state of vitamin D toxicity. The normal range for blood concentration is 30.0 to 74.0 nanograms per milliliter (ng/mL). == Signs and symptoms == Symptoms of vitamin D toxicity may include the following: * Dehydration * Vomiting * Decreased appetite * Irritability * Constipation * Fatigue * Muscle weakness *Metastatic calcification of the soft tissues An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. In addition, hypertension can result. Hypervitaminosis D symptoms appear several months after excessive doses of vitamin D are administered. In almost every case, a low-calcium diet combined with corticosteroid drugs will allow for a full recovery within a month. Research has also indicated that Vitamin D toxicity is closely related to a depletion of Vitamin K and that repletion of Vitamin K allows individuals to supplement with higher doses of Vitamin D without the negative calcium-related side effects. A loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.〔(【引用サイトリンク】title=Cp vs time - iv infusion with loading dose )〕 Another name for a single high-dose oral vitamin D(3) is stoss therapy. A single oral dose of 600,000 IU of cholecalciferol rapidly increases levels of calcifediol, or 25-deoxy-cholecalciferol (), and reduces levels of parathyroid hormone (PTH) in young people with vitamin D deficiency. A cholecalciferol loading dose guideline for vitamin D-deficient adults has been developed. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hypervitaminosis D」の詳細全文を読む スポンサード リンク
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